| Rank | Team | Comments | Prior |
| 1 |  | Florida | Florida routs Michigan in a CWS Finals rematch on Saturday. Gators outscored their opposition 38-1 in four games. | 1 |
| 2 |  | Michigan | The Wolverines were run-ruled by Florida, but they did go 4-1 at the USF/DeMarini-Wilson Tournament. | 2 |
| 3 |  | Auburn | Auburn was absolutely lethal offensively by scoring at least nine runs in every game this week.
| 4 |
| 4 |  | Oregon | The Ducks fell short in a slugfest with Kentucky, but were outstanding offensively all weekend long. | 3 |
| 5 |  | Alabama | Alabama ran into a buzzsaw in UCF on Friday night but recovered to go to 4-1 at the UCF Knights Invitational.
| 6 |
| 6 |  | LSU | The Tigers did get surprised by Pacific on Saturday night, but overall had a pretty good first weekend.
| 5 |
| 7 |  | UCLA | Head Coach Kelly Inouye-Perez won her 400th career game on Saturday as the Bruins went 4-1 in College Station.
| 8 |
| 8 |  | Louisiana | Ragin' Cajuns go 5-0 this week, outscoring opponents 54-6. A showdown with Oregon at Lamson Park is next up. | 12 |
| 9 |  | Florida State | The young Seminoles put together a solid 4-1 weekend down at the Juiceblendz Softball Invitational in Miami. | 9 |
| 10 |  | Missouri | Missouri was off this week and will open the 2016 season next week at the Citrus Classic in Kissimmee, Florida. | 11 |
| 11 |  | Washington | A fantastic start for Washington with wins over Minnesota and Oklahoma. UNLV is next on Monday in Vegas. | 18 |
| 12 |  | Georgia | The Bulldogs have little trouble with Elon and Winthrop as they went 4-0 with relative ease. | 15 |
| 13 |  | Oklahoma | Oklahoma bounced back from losses to Minnesota and Washington to go 3-2 in Las Vegas this week. | 7 |
| 14 |  | Baylor | Baylor took two of three from McNeese State and will need to shore things up defensively moving forward.
| 14 |
| 15 |  | Arizona | Arizona starts the 2016 season off strong with six straight dominating wins.
| 16 |
| 16 |  | Tennessee | Tennessee grinded their way to a 4-2 record in Tempe with losses to Fresno State and Arizona State. | 10 |
| 17 |  | Kentucky | Kentucky got great wins over Oregon and Notre Dame to highlight a 3-1 start to the 2016 season.
| 21 |
| 18 |  | Minnesota | Minnesota just could not slow down Washington late on Sunday, but got a big win over Oklahoma on Friday. | 13 |
| 19 |  | California | Cal got off to a solid 3-1 start after blowing a 2-0 lead in their opener against Wisconsin on Friday. | 20 |
| 20 |  | James Madison | JMU gets a nice split of two games against Alabama and UCF as they went 4-1 at the UCF Knights Invitational.
| 22 |
| 21 |  | UCF | The Knights get a signature win over Alabama on Friday night, but lose a heartbreaker to James Madison on Saturday.
| 24 |
| 22 |  | Texas A&M | The Aggies get a split of two games with UCLA to highlight a 4-1 opening week of the season. | 25 |
| 23 |  | Arizona State | Arizona State got a big confidence boosting win over Tennessee 5-4 on Saturday. Kentucky is next on Monday. | NR |
| 24 |  | Notre Dame | Notre Dame battled their way to a win over Utah and fell short against Kentucky and Cal and went 3-2 in Tempe. | 19 |
| 25 |  | South Alabama | The Jaguars pitched very well enroute to a very solid 5-0 start to the 2016 season. | NR |
